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Clinical and Experimental Otorhinolaryngology > Volume 14(3); 2021 > Article
Kwak, Kim, Bae, Moon, Kim, Choi, and Jung: Effects of Contralateral Routing of Signal Hearing Aids on Audiological and Academic Performance in School-Age Children With Unilateral Hearing Loss
The recent introduction of newborn hearing screening programs for the early detection of unilateral hearing loss (UHL) has received increasing attention. In the 1980s, studies revealed that patients with UHL have increased risks for difficulties in language-related and other development areas [1,2]. In addition, UHL may increase behavioral problems and lead to lower academic achievement [3]. A common nonsurgical option for patients with UHL is to use a contralateral routing of signal (CROS) system [4]. Kenworthy et al. [5] showed that CROS systems can be useful in specific classroom settings by reporting positive audiological outcomes. To date, few studies have evaluated school performance-related auditory behaviors following auditory rehabilitation in school-age patients with UHL, because of the issue of compliance with the use of hearing aids (HAs). Herein, we prospectively assessed the effects of CROS HAs on school-age participants with UHL, focusing on audiological outcomes and auditory behaviors through the use of related questionnaires.
A total of eight participants, comprising five female and three male schoolchildren with UHL, were prospectively enrolled. Their characteristics are shown in Supplementary Table 1. The participants ranged in age from 7 to 13 years (mean age, 10.2±1.8 years). The average hearing threshold in the affected ear was 95.9±21.8 dB HL. Most showed severe or profound hearing loss, except for one participant who had an average hearing threshold of 58.75 dB HL. All of the contralateral ears displayed normal hearing (6.6±7.4 dB HL). This study was conducted in accordance with the recommendations of the Institutional Ethics Committee (No. 4-2017-1541). Written informed consent was obtained from the legal guardians of all minors and children in this study at the time of enrollment.
ReSound LiNX 3D LT562-DRW Receiver-In-Ear HAs with 12 channels were employed in the better-functioning ears, and SureFit CROS transmitters with wires were placed in the poorerfunctioning ears of the study participants (GN Hearing A/S, Ballerup, Denmark). The CROS HAs were fitted by experienced audiologists using the ReSound Aventa fitting program, as recommended by the manufacturer. The mean daily use time of the CROS HAs was 3.5±2.2 hours.
All participants underwent pure-tone and speech audiometry, sound localization assessment, the Korean version of the Hearing in Noise Test (K-HINT), and behavioral tests using questionnaires prior to being fitted with CROS HAs. Follow-up testing was conducted 3, 6, and 12 months later. The questionnaire of the Korea National Institute for the Special Education-Auditory Behavioral Checklist (KNISE-ABC) was used to measure educational performance in school (Supplementary Material 1). The KNISE-ABC is composed of seven subcategories of questions covering listening, listening in background noise, communication, auditory attention, auditory memory, learning, and related behaviors.
Audiological outcomes and the results of auditory behavior testing were compared and analyzed with repeated-measures one-way analysis of variance (ANOVA). The Tukey correction was applied for the post-hoc analysis of between-group and within-group comparisons. Data are presented as mean±standard deviation. Differences between the mean values of groups were considered statistically significant at P<0.05.
The serial root-mean-square error (RMSE) results, including those in the unaided state, are shown in Fig. 1A. Repeated-measures ANOVA revealed that the RMSE differed significantly between the immediate CROS-aided state (49.8°±35.8°) and the CROS-aided state at 12 months (29.3°±30.6°, P=0.01). Initially, the CROS-aided state seemed to yield a higher RMSE degrees than did the unaided state; however, no significant difference was observed between the two. We analyzed improvements in speech perception under noisy conditions using the K-HINT. When noise was delivered from the ipsilateral side (the deaf side), there were no improvements in signal-to-noise ratio (SNR) between the unaided and CROS-aided states at any point (Fig. 1B). In contrast, SNR showed significant enhancement when noise was delivered from the contralateral and front positions in the CROS-aided state compared with the unaided state at 3, 6, and 12 months after fitting the CROS HAs (P<0.05) (Fig. 1C and D). In addition, composite scores collected at 3, 6, and 12 months after fitting the CROS HAs were significantly better than those collected in the unaided state (P<0.01) (Fig. 1E). Individual changes in K-HINT outcomes after CROS HA use are shown in Supplementary Fig. 1.
The obtained KNISE-ABC scores were compared with those of 1,045 school-age children (mean age, 9.1±2.1 years; age range, 5–12 years; 518 male and 517 female) with normal hearing and 18 cochlear implant (CI) patients (12 bilaterally implanted and 6 unilaterally implanted, 11 male and 7 female) with congenital hearing loss among school-aged children (mean age, 10.5±2.0 years) surveyed in prior published studies (Fig. 2, Supplementary Table 2) [6,7]. In the untreated state, all sections except learning garnered lower test scores than those of school-age children with normal hearing. In addition, the KNISE-ABC results were similar to those of CI patients in all sections except learning. However, after using the CROS HAs, the scores for listening in background noise at 6 months and communication at 12 months improved relative to those of CI patients. The scores for related behaviors recorded in the unaided state were poorer than those of the schoolchildren with CIs; however, after fitting the CROS HAs, this difference disappeared. After 12 months of using the CROS HAs, the recorded scores exhibited no differences between the normal school-age children and our participants in auditory attention, auditory memory, and learning. Since all CIs in the previous study were bilateral systems, the better outcomes of the KNISE-ABC in children with UHL are striking. However, there were no significant differences between the unaided state and the use of CROS-HA; only related behavior after 6 months of CROS-HA use was better than in the unaided state.
Some studies have reported that CROS HAs had a negative effect on localization abilities, disrupting the monaural level and spectral cues for localization in the horizontal plane [8,9]. However, our results indicated no difference between unaided and aided states, in agreement with many other studies [10]. In fact, after 12 months of using the CROS HAs, RMSE scores were significantly better than those recorded immediately after the onset of CROS HA use. It seems that the participants became increasingly comfortable and well-adapted to using CROS HAs over the 12 months of the study. This may be attributable to the young age and high auditory plasticity of the participants. In summary, CROS HAs represent a nonsurgical intervention with the potential to improve school performance in children with UHL, encouraging efforts for the rehabilitation of children with UHL.

CONFLICT OF INTEREST

Sung Huhn Kim is an associate editor of the journal but was not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.

Notes

AUTHOR CONTRIBUTIONS

Conceptualization: JJ. Data curation: SHB. Methodology: DK. Project administration: ISM, JYC, SHK. Writing–original draft: SHK. Writing–reviewing & editing: JJ.

ACKNOWLEDGMENTS

The authors would like to thank GN ReSound, Korea for scientific discussions about this project. This research was supported by the Research Program through the National Research Foundation of Korea (NRF) funded by the Korea government (2020R111A1A0107397611).

SUPPLEMENTARY MATERIALS

Supplementary materials can be found via https://doi.org/10.21053/ceo.2020.02523.
Supplementary Table 1.
Participants’ demographics
ceo-2020-02523-suppl1.pdf
Supplementary Table 2.
KNISE-ABC
ceo-2020-02523-suppl2.pdf
Supplementary Fig. 1.
Individual changes of outcomes in Hearing in Noise Test after contralateral routing of signals hearing aid use in children with unilateral hearing loss. Speech perception in noise was measured as signal-to-noise level (dB). SNR, signal-to-noise ratio.
ceo-2020-02523-suppl3.pdf
Supplementary Material 1.
Auditory behavior checklist, ABC
ceo-2020-02523-suppl4.pdf

Fig. 1.
(A) Outcomes of sound localization testing after contralateral routing of signal (CROS) hearing aid (HA) fitting in children with unilateral hearing loss (UHL). The ability of sound localization was measured as the root-mean-square error (RMSE) degree. The test was assessed at initial HA fitting (in both the unaided and CROS HA-aided states) and at 3, 6, and 12 months after HA fitting. (B-E) Outcomes of the Korean version of the Hearing in Noise Test (K-HINT) after CROS HA use in children with UHL. The composite scores were calculated using the formula: [2×noise front+noise right+noise left]/4. Speech perception ability was evaluated in three types of noise environments (ipsilateral side, contralateral side, and front) in both the unaided and CROS HA-aided states. The K-HINT was administered at the initial HA fitting (in both the unaided and CROS HA-aided states) at 3, 6, and 12 months after HA fitting. SNR, signal-to-noise ratio. *P<0.05, **P<0.01.
ceo-2020-02523f1.jpg
Fig. 2.
Evaluation of school performance after contralateral routing of signal (CROS) hearing aid (HA) use in children with unilateral hearing loss (UHL). To evaluate school performance after CROS HA fitting, the Korea National Institute for the Special Education-Auditory Behavioral Checklist (KNISE-ABC) questionnaire was used. The KNISE-ABC consists of seven test areas: listening, listening in background noise, communication, learning, auditory memory, auditory attention, and related behaviors. The blue line indicates mean test results for schoolchildren with normal hearing [6]. The red line indicates the results for 18 elementary schoolchildren with cochlear implants (CIs) [7]. The red asterisks indicate statistical significance between CI and CROS HA users (P<0.05). The blue asterisks indicate statistical significance between schoolchildren with normal hearing and CROS HA users (P<0.05). + refers to the mean scores of study participants.
ceo-2020-02523f2.jpg

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