Efficacy of Tympanoplasty Without Mastoidectomy for Treating Chronic Otitis Media in Patients With Mastoid Cavity Opacification in Temporal Bone Computed Tomography Findings

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Abstract

INTRODUCTION

The efficacy of mastoidectomy combined with tympanoplasty for treating chronic otitis media (COM) in patients without cholesteatoma remains controversial among otologists. One issue is whether mastoidectomy should be routine when tympanoplasty is performed [1]. Some suggest that mastoidectomy is effective only in patients with suppurative otitis media, and not in those with dry ears [2]. The utility of mastoidectomy is considered uncertain, especially in terms of outcomes [3,4].

Today, temporal bone computed tomography (TBCT) plays a key role in COM diagnosis and the choice of surgical intervention [5,6]. Air cells of the mastoid cavity and mucosa play important roles in gas exchange, both in the middle ear and mastoid cavity [7]. It may thus be better to preserve, rather than remove, the cavity. Mastoidectomy is unnecessary if the mastoid cavity is clear on TBCT. However, the general view is that mastoidectomy is appropriate when COM is associated with opacification of mastoid cavity.

In terms of physiological recovery, a chronically infected mastoid mucosa will scar during tissue repair [8]. A scar may be physiologically protective, combining with sclerotic bone formation to improve Eustachian tube function. Scar tissue developing in the mastoid cavity after medical and clinical treatment also presents as soft tissue opacification on TBCT. Thus, it may be unwise to remove such tissue via mastoidectomy. We considered that tympanoplasty without mastoidectomy might be a better surgical option for COM patients with soft tissue opacification on TBCT. We thus explored whether tympanoplasty without mastoidectomy was appropriate to treat COM patients in whom TBCT revealed mastoid air cell opacification.

MATERIALS AND METHODS

A total of 33 ears, of COM patients who had undergone tympanoplasty alone (i.e., without mastoidectomy) and in whom TBCT revealed mastoid cavity opacification, were retrospectively reviewed. All operations were performed by a single surgeon (YHC) at a tertiary referral center (Ajou University Hospital, Suwon, Korea) between 2010 and 2014. Our inclusion criteria were COM without cholesteatoma, no otorrhea for ≥3 months prior to enrolment, and clear middle ear mucosa upon microscopic examination in the operating room. We analyzed preoperative otoscopic findings, pre- and postoperative pure tone averages (PTAs), TBCT images, surgical procedures, and complications or recurrence. Postoperative hearing outcomes were assessed using the relevant Korean guidelines [9]. Surgery was considered successful if the postoperative air-bone gap was <20 dB, the gain in air conduction hearing was >15 dB, or the postoperative air conduction hearing level was <30 dB, and when such improvements were assessed by postoperative PTAs performed at least ≥6 months after surgery [9]. This study was performed with the approval of the Institutional Review Board of Ajou University School of Medicine, Korea (IRB No. AJIRB-MED-MDB-17-178). The informed consent was waived.

Soft tissue opacification of mastoid cavity was evaluated by radiologists. Postoperative TBCT was performed if a complication or recurrence was suspected, and to evaluate the opposite side in patients with bilateral COM.

The paired t-test was used to assess statistical significance. All statistical analyses were performed with SPSS ver. 18.0 (SPSS Inc., Chicago, IL, USA). A P-value <0.05 was considered to indicate statistical significance.

RESULTS

Table 1 shows the baseline characteristics of the study population. The mean patient age was 44±12 years and seven ears underwent not only tympanoplasty, but also ossiculoplasty (without mastoidectomy). The mean follow-up period was 19.6±13.4 months and the minimum period was 6 months.

Table 1.

Patient characteristics

Hearing results

Twenty-eight patients (84.8%) fulfilled at least one of the success criteria described above [9]; five (15.2%) did not. The mean pre- and postoperative PTAs of the 28 successful patients were 46.9±21.2 dB and 29.4±17.0 dB, respectively (P<0.001). The mean pre- and postoperative air-bone gaps of them were 25.7±10.7 dB and 10.3±8.7 dB, respectively (P<0.001) (Fig. 1).

Fig. 1.

Audiometric evaluation of the successful 28 patients. Both air conduction and the air-bone gap improved significantly.

Complications and recurrences

Of the 28 patients exhibiting postoperative hearing gains, one complained of a small tympanic perforation after surgery and underwent fat tissue myringoplasty. Overall, >80% of patients enjoyed hearing gains without any complication or recurrence. Attic destruction was developed in one patient during follow-up; we performed revision tympanoplasty with mastoidectomy. Otoscopic examination revealed otorrhea around tympanic membrane in two patients. These two cases exhibited granular myringitis without a tympanic perforation, which resolved rapidly on application of otic drops. Two patients whose hearing did not improve after tympanoplasty underwent additional ossiculoplasty and further observation (Fig. 2).

Fig. 2.

Complications and their management after tympanoplasty. Mastoidectomy was performed on one patient because of progressive attic destruction after surgery. Overall, >80% of patients experienced better hearing outcomes without any complications.

Follow-up TBCT

We performed TBCT after surgeries in seven patients who had ear diseases on the opposite side, complained otorrhea or hearing impairment after surgeries, or were suspicious the possibility of cholesteatoma during follow-up period. In four patients, the preoperative status of the middle ear and mastoid cavity did not change (Fig. 3). The other three patients exhibited no mastoid cavity opacification (Fig. 4).

Fig. 3.

No change in opacification was evident on follow-up temporal bone computed tomography of four patients. (A) A 22-year-old female: type I tympanoplasty, left. (B) A 47-year-old male: type III tympanoplasty, left. (C) A 42-year-old female: type III tympanoplasty, left. (D) A 52-year-old female: type I tympanoplasty, right.

Fig. 4.

Resolution of mastoid cavity haziness during post-tympanoplasty follow-up temporal bone computed tomography. (A) A 68- year-old male: type I tympanoplasty, right. (B) A 42-year-old female: type I tympanoplasty, right. (C) A 55-year-old female: type I tympanoplasty, right.

DISCUSSION

The middle ear cavity plays an important role in sound conduction, especially by reserving air. There are two principal ear pressure regulation systems, namely Eustachian tube functionality and gas exchange, principally in the mastoid mucosa [10,11]. Takahashi et al. [7] analyzed gas exchange functionality after 14 ear surgeries, showing that it clearly correlated with preservation of the mastoid mucosa. Specifically, mastoidectomized ears lacked gas exchange functionality because the mastoid cavities were filled with thick scar tissue with only a few capillaries [7]. Thus, mastoid cavity preservation is important. However, mastoidectomy is required in certain pathophysiological situations, especially cholesteatoma. This is why great efforts are being made to use tissue engineering to regenerate mastoid cavity air cells [12]. A normal mastoid cavity mucosa is clearly preferable to mastoidectomized or scaffolded regenerated tissue. Therefore, if tympanoplasty alone resolves Eustachian tube obstruction and improves aeration, mastoidectomy is not required.

The significance of mastoid cavity opacification on TBCT requires consideration. In cholesteatoma, for example, opacification reflects a progressive pathological condition that must be eradicated via mastoidectomy. On the other hand, in patients with COM without cholesteatoma, it is doubtful that opacification indicates a pathological lesion that will later trigger disease recurrence. Recently, Wilkinson et al. [13] reported that the prevalence of incidental mastoid cavity and middle ear opacification on TBCT was 11% in adults without traumatic or otological medical histories.

It has been speculated that mucosal thickening evident on TBCT is a self-limiting process [14]. In terms of tissue repair [8], scars (evident as soft tissue on TBCT) may include normal part-regenerated mucosa active in gas exchange; the scar tissue is thus valuable and should not be removed. A mastoidectomized cavity becomes filled with thick scar tissue lacking any gas exchange function [7].

We found that tympanoplasty alone afforded hearing gains in 84.8% of patients. Attic destruction developed in one patient 11 months after surgery. This indicates that accurate differential diagnosis of COM and cholesteatoma is essential; cholesteatoma patients require mastoidectomy. This was the only case of disease recurrence after operation.

Seven patients underwent follow-up TBCT (Figs. 3, 4). Four cases showed no mastoid cavity changes over time. If the opacification was progressively pathological, adjacent bone destruction would be evident; however, this was not the case, even in the patient with attic destruction (Fig. 3). Fig. 4 illustrates the three cases in whom opacification decreased. We assume that this represented effusion, not scar tissue formation. Effusion is easy to manage on an outpatient basis because no surgery is required.

All 33 cases had undergone medical and clinical management for ≥1 year prior to surgery. Fig. 4 emphasizes the importance of preoperative management (meticulous ear dressing, otic drops, and/or antibiotics). Comprehensive evaluation, including medical history-taking, otoscopic examination, and a period of medical treatment prior to surgery, are critical, as is professional radiological assessment [15].

We suggest that tympanoplasty alone (i.e., without mastoidectomy) when mastoid cavity opacification is evident on TBCT is appropriate when (1) COM is not accompanied by cholesteatoma; (2) the middle ear has been dry for ≥1 year; and (3) sclerotic change is evident in the mastoid cavity. The dry period was ≥3 months in the present study; a longer period would be preferable. Although radiologists seek to differentially diagnose mastoid haziness [15], it is not easy to distinguish between chronic scar tissue and an acute lesion. Our experience (and the findings of Lo and Nemec [15]) suggest that sclerotic change in a retracted mastoid may be key in this context. Clinically, compared to the opposite mastoid, opacification with sclerotic changes indicates mucosal recovery with scar formation, and the mastoid is preserved.

Our study had certain limitations. If our 33 patients had been compared with a group who underwent simple mastoidectomy, the efficacy of tympanoplasty alone would have been clearer. A case-control study is required to confirm our findings. Furthermore, our mean follow-up time was only 19.6 months; long-term follow-up is required.

Tympanoplasty alone may be effective for COM patients even if the mastoid cavity is opaque on TBCT. Before tympanoplasty is performed, the middle ear must be dry. The hearing levels and pre- and perioperative findings must be considered. We suggest that tympanoplasty alone (i.e., without mastoidectomy) is appropriate for patients with COM without cholesteatoma, whose ears have been dry for ≥3 months and who exhibit sclerotic changes in the mastoid cavity.

HIGHLIGHTS

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